Zenflore by PrecisionBiotics – Daily Food Supplement - Unique 1714-Serenitas Live Bacterial Culture Plus Vitamins B6 and B12 - Helps Reduce Fatigue and Supports Mental Performance - 30 Capsules

Product Information

The culture in Zenflore is known to be involved in regulating your immune system, which plays an important role in health and well-being. When combined with these vitamins, Zenflore® helps fight fatigue. In addition, clinical trials have demonstrated that the encapsulated 1714-Serenitas® strain reaches the gut alive, giving maximum efficacy. The beneficial culture 1714-SerenitasⓇ occurs naturally in the digestive system and is a member of the Bifidobacteria family of bacteria passed from mother to baby in breastmilk. This unique culture was isolated and developed by PrecisionBiotics® in association with their esteemed colleagues at the Alimentary Health Group in Co. Cork, Ireland, a world-leading institute in gut health, microbiome, and gut-brain axis research. Brain magnetic fields were measured with a 275-channel whole-head MEG (CTF Omega, Port Coquitlam, Canada). Participants were studied in sitting position. During each session, 5 minutes resting state was recorded before playing the CBG. During the resting state, participants were instructed to move as little as possible and to stay alert while keeping their eyes closed. During the CBG, task instructions were projected onto a screen in front of the participants using a video projector and a mirror system. MEG signals were sampled at a rate of 585.94 Hz with an anti-aliasing filter set to 146.49 Hz.

We’ve long known of a connection between the stomach and the brain. ‘Butterflies’ in the stomach and ‘gut-wrenching’ feelings are clear examples of this phenomenon. Information is sent instantly from the gut to the brain via the nervous and immune systems, and through hormones (the endocrine system). A key channel for communication is through the vegas nerve, which relays neurotransmitters to the brain. Around 90% of this information is one-way traffic from the gut to the brain. The 1714-Serenitas® strain in Zenflore® increases activity in the part of the brain that commands our emotional responses. E.g. Gut bacteria are important for the communication with the brain. They produce neurotransmitters (such as cortisol, serotonin and dopamine) and other microbial metabolites, and by stimulating immune cells to produce chemical messaging compounds (cytokines) that reach the brain. Signs of stress: what to look out for Other convincing studies have shown the same probiotic strain may also have a positive effect on memory. While other strains have been studied looking at their effects on the brain, the company responsible for the research and development on bifidobacterium longum 1714 has taken a pharmacological approach, by rigorously testing it in three phases. Most of us have had 'gut reactions’ to things in our lives; 'gut feelings’ about people or events. But a growing body of research is showing these may be more accurate than we could ever have imagined. Poor sleep is associated with increased inflammation in the body and probiotics have been shown to regulate the immune system and have anti-inflammatory effects so that could be another way that probiotics and gut bacteria could influence sleep,’ Dr Murphy explains. The strain to look for Indeed, a consumer survey of Zenflore – a daily probiotic that has been shown in peer-reviewed medical research to help cope with everyday stress – users found that of those taking it, one in four had seen an improvement in their sleep, most of them after 2-4 weeks of use. Could your gut bacteria be affecting your sleep?Accumulating evidence indicates that the gut microbiota communicates with the central nervous system, possibly through neural, endocrine, and immune pathways, and influences brain function. B. longum 1714™ has previously been shown to attenuate cortisol output and stress responses in healthy subjects exposed to an acute stressor. However, the ability of B. longum 1714™ to modulate brain function in humans is unclear. METHODS: Louise Riis can’t remember a time when she hasn’t struggled to get to sleep. ‘I have had sleep problems since I can remember and they have always been in response to stress – exams, new jobs, work pressure…If something new or stressful happens in my life, my sleep is the first thing to go,’ says the 42 year old lifestyle blogger. Those who regularly sleep badly will be familiar with the myriad of potential fixes on offer. Exercise might help, as might certain nutrients, teas or foods. Then, of course there is always the option of benzodiazepines such as Xanax and Valium, but their addictive potential has been well documented and doctors constantly advise against taking them. Evidence shows that bacteria in the gut can act on the gut-brain axis and hence influence gut-brain communications.

In this study, we explored the effect of B. longum 1714™ on brain function in response to social stress in a randomized, double-blinded, placebo-controlled trial, using the neuroimaging method magnetoencephalography (MEG). Social stress was induced by social exclusion/rejection ( 11) through a standardized paradigm, called “Cyberball Game” (CBG) ( 12). According to a recent review summarizing previous neuroimaging studies on the CBG, regions of the prefrontal cortex (PFC), anterior cingulate cortex (ACC), and temporal cortex are involved in neural processing of this type of social stressor ( 13). Indeed, social stress during the CBG is consistently associated with altered neural oscillations in certain brain areas, such as alpha band power in frontal cortex and theta band power in the ACC and insula ( 14–17). Difference in neural activity change during the Cyberball game comparing B. longum 1714™ vs placebo. ( a) Theta band showed an increased power in a cluster, consisting of the right inferior frontal cortex (IFC) and the bilateral middle frontal cortex (MFC) and superior frontal cortex (SFC), the left anterior cingulate cortex (ACC), the bilateral middle cingulate cortex (MCC), and the right supramarginal gyrus (SMG), comparing B. longum 1714 group and the placebo group in both conditions ( P = 0.03). ( b) Alpha band power also showed an increased power in cluster, including regions of the right IFC, the bilateral MFC and SFC, the bilateral ACC and MCC, and the right SMG, comparing B. longum 1714™ group and the placebo group in both conditions ( P = 0.04). No main effects of condition or interaction of intervention and condition were observed. B. longum 1714™–induced change in neural activity in social stress correlated with changes in distress levels Corn starch, Gelling agent: hydroxypropyl methyl cellulose, nicotinamide, bacterial culture*, calcium D-pantothenate, Anti-caking agent: magnesium stearate, Vitamin B12 (cynaocobalamin), Vitamin B6 (pyridoxine hydrochloride), riboflavin, thiamine hydrochloride, folic acid (pteroylmonoglutamic acid), D-biotin. *B. longum 1714-Serenitas Yes. ZenfloreⓇ is suitable for children over the age of 3 years. Please consult your healthcare practitioner for further advice.The best prebiotics are chicory roots, Jerusalem and globe artichokes, leeks, onions, garlic, celery, bananas, apples and pears. The microbes in your gut also feed off foods containing antioxidants called polyphenols found in seeds, nuts, extra virgin olive oil, coffee, dark chocolate and wine (for gut-friendly diets, a varied Mediterranean diet is useful). And while the NHS recommends exercise as a viable solution, and countless studies show its effectiveness as a mood enhancer, often the last thing you want to do is go jogging five times a week. Yes. There are no known allergens in ZenfloreⓇ. All ingredients used in manufacture do not contain any allergen listed in the Directive 2007/68/EC and its amendments. ZenfloreⓇ is free from gluten, dairy, soya, and lactose. We’ve long known of a connection between the stomach and the brain. Butterflies in the stomach and ‘gut-wrenching’ feelings are clear examples of this phenomenon. Information is sent instantly from the gut to the brain via the nervous and immune systems and hormones (the endocrine system).